Mesenchymal
extract to regenerate functional tissues and energy level
Mesenchymal extract is prepared from
mammal extra-embryonic connective tissue and, like other
gland extracts, also has a long history of use. Dr. Niehans
(a reputed Swiss endocrinologist) already used it in the
thirties to rejuvenate aging cells (Niehans, 1960).
Mesenchymal stem cells are undifferentiated cells that,
when triggered under appropriate conditions, can become
almost any type of cells to help restore damaged or aging
tissues (Caplan, 1994). Mesenchymal extract is obtained
by breaking down mesenchymal stem cells to liberate active
molecules. These active molecules are then selectively
picked up through a special patented process to obtain
a mesenchymal liquid extract that provides a natural rich
source of cellular growth factors and other signaling
molecules.
Myalgia is a significant feature of CFS.
The diffuse muscle pain seen in CFS is, in fact, quite reminiscent
of that observed in fibromyalgia, a rheumatoid disease.
Recent studies have linked insufficient plasma levels of growth
hormone to both conditions (Berwaerts, 1998; Bennet, 2002)
and administration of growth hormone to patients with fibromyalgia
was able to reduce pain symptoms (Leal-Cerro, 1999).
Mesenchymal extract, being a rich source of growth factors,
is expected to be helpful in reducing the chronic pain experienced
by many CFS sufferers.
Additionally, as demonstrated in our laboratories,
mesenchymal extract has the capacity to increase mitochondrial
metabolism, the primary aerobic source of energy for
cells (Fig. 4). This in vitro experiment demonstrated
that NatCell Mesenchyme contains a biological activity
capable of inducing aerobic respiration (WST-1 mitochondrial
activity) in fibroblast, while negligibly affecting
their proliferation (Hoescht DNA count). Embryonic
bovine serum was present at a minimal concentration
in the cell culture milieu, as a source of general growth
nutrients to maintain cell viability. This biological
activity profile is of primary importance for NatCell
Mesenchyme to support its use as a nutritional supplement
especially in physiological conditions for which an
increase in cellular metabolic activity may bring benefits.
This is certainly the case in CFS.
Figure
4. Effect of NatCell Mesenchyme on fibroblast mitochondrial
activity and proliferation
Muscle
weakness is a common symptom among CFS patients and
is believed to be linked to reduced oxidative metabolism
(McCully, 1996) caused by some mitochondrial defect
(Behan, 1991). As reduced mitochondrial oxidative
phosphorylation directly affects ATP synthesis, there
is less energy available for physical activity.
As a metabolic booster, Mesenchymal cell extract may
help restore the body energy level to relieve the
fatigue and muscle pain of CFS patients. As
a result, Mesenchymal cell extract should increase
their capacity to exercise, itself an important step
in the recovery process.
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